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. 2010 Aug 13;5(8):e12174. doi: 10.1371/journal.pone.0012174

Figure 5. LAIR-2/Fc interferes with VWF binding to collagen.

Figure 5

Microtiter wells were coated with 50 µg/ml collagen I (panel A) or collagen III (panel B) and subsequently incubated with 0.1 µg/ml purified plasma-derived VWF in the presence of increasing concentrations of LAIR-1/Fc (open circles), LAIR-2/Fc (closed circles) or SIRL-1/Fc (squares). VWF binding was detected with horseradish-conjugated polyclonal anti-human VWF antibodies and 3-3′-5-5′-tetramethylbenzidine. Data are representative of 3 independent experiments.