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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Med Primatol. 2010 Aug;39(4):194–212. doi: 10.1111/j.1600-0684.2010.00432.x

Figure 5. Developmental interaction between MHC class I and cognate inhibitory receptors ‘educate’ NK cells to respond to missing self.

Figure 5

Shown are the results of assays in which peripheral blood NK cells are cultured with target cells of the class I deficient 221 B cell line. Using flow cytometry selected subsets (either expressing CD94:NKG2A or KIR3DL1) of NK cells were analysed for presence of intracellular interferon-γ. Blood donors were selected based upon their HLA class I and KIR types. All donors carried the Bw4 epitope. For further details see Yawata et al [52].

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