Table 1. Functional annotation of the sex-independent cluster.
Ontology | Keywords | P-value |
Acute phase response (ES : 4.3–25 genes)SAA1, SAA2, SAA3, SAA4, ORM3, SERPINA3N, C8a, C9 | ||
SP_PIR_KEYWORDS | Acute phase | 2.9×10−6 |
GO_BP | Acute-phase response | 6.4×10−6 |
GO_BP | Acute inflammatory response | 1.8×10−5 |
INTERPRO | Serum amyloid A protein | 8.6×10−5 |
SMART | SAA | 6.1×10−6 |
Lipid metabolism (ES : 3.9–38 genes)CRAT, ACOX1, ACOT2, ACOT5, EHHADH, ACAA1A, CPT1B, PLTP | ||
GO_BP | Fatty acid metabolic process | 1.3×10−7 |
GO_BP | Monocarboxylic acid metabolic process | 9.1×10−9 |
SP_PIR_KEYWORDS | Fatty acid metabolism | 8.4×10−6 |
BO_BP | Lipid metabolic process | 1.6×10−9 |
GO_CC | Peroxysome | 3.3×10−5 |
GO_CC | Microbody | 3.3×10−5 |
Steroid metabolic process (ES : 3.3–14 genes)STAR, IDI1, MOGAT1, LEPR, FABP5, PCTP, AKR1C18, FBP2, HMGCS1 | ||
GO_BP | Steroid metabolic process | 1.7×10−4 |
GO_BP | Alcohol metabolic process | 5.5×10−4 |
GO_BP | Cholesterol metabolic process | 6.8×10−4 |
GO_BP | Sterol metabolic process | 1.0×10−3 |
Thrombospondin (ES : 1.8–5 genes)SPON2, C9, SEMA5B, ADAMTS20, C8A | ||
SMART | TSP1 | 1.7×10−3 |
INTERPRO | Thrombospondin, type I | 1.9×10−3 |
The enrichment score (ES), the number of genes and example genes in each group of genes were indicated.