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. Author manuscript; available in PMC: 2010 Aug 13.
Published in final edited form as: J Immunol. 2009 Nov 30;184(1):84–93. doi: 10.4049/jimmunol.0901590

FIGURE 3.

FIGURE 3

Treatment with the SFK inhibitor PP2 results in increased levels of IL-6 and IL-13 production in Ag-stimulated B6 and WeeB but not lyn−/− BMMCs. A, Cells were sensitized with anti-DNP IgE 206 overnight, pretreated with the indicated concentrations of PP2 or vehicle (DMSO) for 15 min, and then stimulated for 16 h with either 100 ng/ml DNP21-BSA or 2 μg/ml anti-IgE. Error bars represent SD. Results shown are representative of three independent experiments. B, Migration assays were performed in Transwell chambers using the indicated concentrations of DNP21-BSA or anti-IgE B1E3 in the lower wells. C, Lysine-DNP pretreatments with the indicated concentrations of monomer (in media) were performed as in A. *p <0.05; **p <0.01 versus the same genotype in the absence of PP2 or lysine-DNP.