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SMAD4 Immunohistochemical scoring. SMAD4 IHC was scored as normal (A), reduced (B) or loss of SMAD4 expression (C). Nuclear staining in the epithelial cells lining normal crypts or inflammatory cells in the mesenchymal stroma on the same section served as internal control. Note loss of SMAD4 expression in non-neoplastic epithelium in C. Magnification 20X.
