. Author manuscript; available in PMC: 2011 Aug 15.

Published in final edited form as: Clin Cancer Res. 2010 Aug 3;16(16):4126–4134. doi: 10.1158/1078-0432.CCR-10-0168

Table 3.

Dysplasia in juvenile polyps and SMAD4, APC, ß-catenin, K-ras and p53 status.

Patient	polyp	Dysplasia	SMAD4 IHC	APC mutation	K-ras mutation	ß-catenin IHC	p53 IHC
1	1.1	LGD	reduced	NM	failed	M	N
	1.2	Neg.	normal	-	-	M	N
2^*	2.1	Indef.	normal	-	-	M	N
	2.2	Neg.	normal	-	-	M	N
	2.3	Indef.	reduced	-	-	M	N
3^*	3.1	LGD	reduced	NM	NM	M	N
	3.2	Indef.	normal	-	-	M	N
4^†	4.1	Neg.	loss	-	-	M	N
5^†	5.1	Neg.	loss	-	-	M	N
	5.2	Neg.	normal	-	-	M	N
6	6.1	Neg.	normal	-	-	M	N
	6.2	HGD	normal	NM	NM	M	A
	6.3	HGD	normal	NM	NM	M	A
7	7.1	LGD	normal	NM	NM	M	A
	7.2	LGD	normal	NM	NM	M	N
	7.3	LGD	loss	NM	Codon 12	M	A
8	8.1	Indef.	loss	-	-	M	A
	8.2a	Neg.	loss	-	-	M	N
	8.2b	LGD	normal	NM	NM	M	A
	8.3	Neg.	normal	-	-	M	N
	8.4a	Neg.	loss	-	-	M	N
	8.4b	LGD	normal	NM	NM	M	N

Patient 2 and 3 and

^†

patient 4 and 5 were from the same family

LGD: low-grade dysplasia. HGD: high-grade dysplasia. Indef.: indefinite for dysplasia. Neg.: negative for dysplasia. NM: no mutation found. M: membranous ß-catenin staining pattern. N: normal p53 staining pattern. A: aberrant p53 staining pattern (i.e. overexpression of absent staining).