Table 2.
Genotype distribution of CSF1R polymorphisms in asthmatics (BA) and normal subjects (NC) of the study subjects
| Loci | Position | rsSNP | Subject | N (%) | Co-dominant | Dominant | Recessive | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C/C | C/R | R/R | OR(95% CI) | p | p corr | OR(95% CI) | p | p corr | OR(95% CI) | p | p corr | ||||
| +20511C>T | Intron11 | rs216144 | NC | 166 (63.4) | 84 (32.1) | 12 (4.6) | 1.55 (1.19–2.00) | 0.001 | 0.02 | 1.67 (1.22–2.28) | 0.001 | 0.03 | 1.85 (0.94–3.65) | 0.07 | 1 |
| BA | 236 (50.5) | 195 (41.8) | 36 (7.7) | ||||||||||||
| +22693T>C | Intron11 | rs216140 | NC | 74 (28.2) | 145 (55.3) | 43 (16.4) | 1.22 (0.98–1.51) | 0.08 | 1 | 0.94 (0.67–1.32) | 0.71 | 1 | 1.99 (1.34–2.95) | 0.0006 | 0.01 |
| BA | 136 (29) | 212 (45.2) | 121 (25.8) | ||||||||||||
* Controlled for age (continuous value), sex (male = 0, female = 1), atopy status (non-atopy = 0, atopy = 1), and smoking status (non-smoker = 0, ex-smoker = 1, smoker = 2) as co-variables. The effective number of independent marker loci in CSF1R was calculated to correct for multiple testing, using the software SNPSpD (http://genepi.qimr.edu.au/general/daleN/SNPSpD) (Nyholt 2004). The number of independent marker loci in CSF1R was calculated as 4.5008 and 20.0301 in ht-block1 and ht-block2