Table 1.
Efficacy of chemotherapeutic agents. Cell lines were treated with resveratrol (20 μM) prior to the addition of various concentrations of 5-FU (1-100 μM), Mitomycin C (1-10 μM) or gemcitabine (1-100 μM). The IC50 dose was calculated as the dose of the chemotherapeutic agent required to inhibit the proliferation to 50% of the untreated cells in an MTS cell proliferation assay
Chemotherapy | Mz-ChA-1 | SG231 | HuCCT-1 | CCLP-1 | H69 | |||||
---|---|---|---|---|---|---|---|---|---|---|
− resv. | + resv. | − resv. | + resv. | − resv. | + resv. | − resv. | + resv. | − resv. | + resv. | |
5-FU | 95.01 μM | 58.99 μM | 61.12 μM | 50.72 μM | 63.09 μM | 43.49 μM | 87.48 μM | 53.07 μM | 206.3 μM | 286.3 μM |
Mitomycin | 9.56. μM | 4.39 μM | 5.40 μM | 1.27 μM | 6.12 μM | 5.15 μM | 7.39 μM | 5.95 μM | 38.93 μM | 21.52 μM |
Gemcitabine | 101.1 μM | 88.18 μM | 100.2 μM | 60.82 μM | 61.0 μM | 34.54 μM | 95.49 μM | 82.45 μM | 237.7 μM | 200.5 μM |