Table 4.
Buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine-glucuronide (BUP-Gluc), and norbuprenorphine-glucuronide (NBUP-Gluc) concentrations in 4 different locations of 5 placenta specimens from buprenorphine-maintained women.
| Participant | Analyte | Location 1 (ng/g) | Location 2 (ng/g) | Location 3 (ng/g) | Location 4 (ng/g) | Mean (ng/g) | CV (n=4, %) |
|---|---|---|---|---|---|---|---|
| A | BUP | 2.5 | 2.7 | 3.2 | 3.2 | 2.9 | 13.0 |
| NBUP | 17.3 | 16.6 | 24.2 | 23 | 20.3 | 19.3 | |
| BUP-Gluc | 3.2 | 2.5 | 3.4 | 2.8 | 3.0 | 14.0 | |
| NBUP-Gluc | 16.0 | 14.0 | 15.9 | 16.2 | 15.5 | 6.6 | |
| B | BUP | 3.1 | 2.5 | 2.4 | 2.0 | 2.5 | 17.4 |
| NBUP | 20.1 | 19.1 | 18.1 | 15.3 | 18.1 | 11.4 | |
| BUP-Gluc | 3.8 | 4.2 | 3.1 | 3.2 | 3.6 | 14.8 | |
| NBUP-Gluc | 14.5 | 13.5 | 13.2 | 11.7 | 13.2 | 8.5 | |
| C | BUP | 1.2 | 1.0 | 0.0 | 0.0 | 0.6 | - |
| NBUP | 8.0 | 6.9 | 6.2 | 6.3 | 6.9 | 12.1 | |
| BUP-Gluc | 5.0 | 4.1 | 3.4 | 3.6 | 4.0 | 17.8 | |
| NBUP-Gluc | 16.2 | 12.6 | 11.4 | 11.9 | 13.0 | 16.7 | |
| D | BUP | 2.4 | 0.0 | 2.0 | 0.0 | 1.1 | - |
| NBUP | 20.6 | 12.0 | 21.5 | 14.2 | 17.1 | 27.5 | |
| BUP-Gluc | 1.5 | 1.3 | 2.0 | 1.4 | 1.6 | 17.4 | |
| NBUP-Gluc | 24.0 | 18.7 | 25.8 | 21.6 | 22.5 | 13.6 | |
| E | BUP | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | - |
| NBUP | 13.6 | 11.5 | 14.5 | 14.2 | 13.4 | 10.1 | |
| BUP-Gluc | 1.5 | 1.8 | 1.9 | 2.0 | 1.8 | 11.2 | |
| NBUP-Gluc | 13.0 | 12.2 | 15.0 | 15.5 | 13.9 | 11.1 |