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Effect of the selective endothelin A receptor antagonist ABT-627 (A) (n=15–18) and the dual endothelin A/B receptor antagonist A-182086 (B) (n=13) on plasma concentrations of 8-isoprostane at baseline (unstressed) and during air jet stress in pre-hypertensive Dahl salt-sensitive rats. Animals were either untreated (week 1), or given ABT-627 (5 mg/kg/day in the drinking water; week 2) or A-182086 (30 mg/kg/day in the food; week 2) for 3 days. *p<0.05
