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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Control Release. 2010 Apr 10;146(2):164–174. doi: 10.1016/j.jconrel.2010.04.008

Fig. 5.

Fig. 5

Pharmacokinetic model for TNF release. Pharmacokinetic parameters were obtained by fitting the blood concentration-time data for gold (CAu) and Au–TNF (CT). The TNF release was estimated using the hyperbolic stability equation, CRel=CT(0)*exp (−k1*t)*(t/(t+t50). The first-order elimination constant (k2) and concentration at time zero (CN(0)) for native TNF (CN) were fixed. The first-order elimination rate for gold (k1), hyperbolic time to 50% TNF release (t50), and time zero concentrations for gold (CAu(0)) and Au–TNF (CT(0)) were obtained from fitting the kinetic model to the data.