. Author manuscript; available in PMC: 2011 Sep 1.

Published in final edited form as: J Control Release. 2010 Apr 10;146(2):164–174. doi: 10.1016/j.jconrel.2010.04.008

Table 1.

Pharmacokinetic parameters for Native TNF, Au-TNF, and Au. Pharmacokinetic parameters determined by noncompartmental analysis of blood time profiles. Data are presented as mean±SD (n=4–5 rats).

	C_max	Vd	AUC	CL	t_1/2
	ug/ml	mL	ug/mL/min	mL/min	min
Native TNF	0.32±0.06	163±31	20.6±2.8	2.6±0.5	26±4
Au-TNF	3.0±0.6	18±4	248±18	0.21±0	182±26
Au	64±20	24±8	21474±6894	0.07±0.03	217±29

AUC, area under the time concentration curve; CL, clearance; Vd, apparent volume of distribution; C_o, concentration at time zero; t_1/2, terminal half-life.