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. Author manuscript; available in PMC: 2010 Aug 16.
Published in final edited form as: Annu Rev Immunol. 2008;26:421–452. doi: 10.1146/annurev.immunol.26.021607.090326

Figure 3.

Figure 3

Models of in vivo MCP-1-mediated monocyte recruitment. During infection, MCP-1 is produced and secreted by microbially infected or by cytokine-stimulated uninfected cells. In the first model (a), secreted MCP-1 establishes a gradient across the distance from infection site and attracts monocytes to infection sites. In an alternative model (b), the MCP-1 gradient is established not by distance from chemokine production site but rather by chemokine binding with specific GAGs. Association with GAGs increases MCP-1 concentration in specific regions and further facilitates oligomerization of MCP-1.