Table 1.
Overview of clinical studies investigating ischaemic postconditioning in acute myocardial infarction.
| Study | Year | IPOC/control(n) | Ischaemia time(hours) | IPOC protocol* | Results | |
|---|---|---|---|---|---|---|
| Enzymatic infarct size | Functional parameters | |||||
| Laskey et al. | 2005 | 10/7 | 5.7 | 2 x 90 s | No difference on peak CK | Improved ST-segment resolutionImproved CFVR |
| Staat et al.6 | 2005 | 14/16 | 5.3 | 4 x 60 s | 36% Reduction 72 h CK | Improved ST-segment resolutionImproved MBG |
| Ma et al.20 | 2006 | 47/47 | 6.6 | 3 x 30 s | Decreased peak CK and CK-MB (p=NS) | Improved WMSI and endothelial functionDecreased MDA |
| Yang et al.21 | 2007 | 23/18 | 5.2 | 3 x 30 s | 27% Reduction 72 h CK | 27% reduction IS SPECT 1 weekImproved LVEF 44-54% 1 week (p=NS) |
| Thibault et al.7 | 2008 | 17/21 | 4.7 | 4 x 60 s | 40% Reduction CK, 47% Reduction TnI | 39% IS Reduction SPECT 6 monthsImproved LVEF 49-56% 1 yearImproved WMSI |
| Laskey et al.22 | 2008 | 12/12 | 3.8 | 2 x 90 s | Decreased peak CK | Improved ST-segment resolutionImproved CFVR |
| Zhao et al.23 | 2009 | 24 and 25/26 | 5.8/4.8 | 3 x 30 s/3 x 60 s | Reduced TnI 1 week (60s>30s>routine) | Improved LVEF 1 week (60s>30s>routine)Decreased apoptosis |
| Lønborg et al.24 | 2010 | 59/59 | 4.0 | 4 x 30 s | Decreased peak TnT (p=NS) | 19% Reduction IS MRI 3 monthsImproved NYHA class 3 months |
* IPOC protocol: number of balloon inflations x inflation duration. CK=creatine kinase, CK-MB=creatine kinase isoenyzme MB, CFVR=coronary flow velocity reserve, IS=infarct size, LVEF=left ventricular ejection fraction, MBG=myocardial blush grade, MDA=malondialdehyde, MRI=magnetic resonance imaging, NYHA = New York Heart Association, SPECT=single photon emission computed tomography, TnI=troponin I, TnT=troponin T, WMSI=wall motion score index.