TABLE 3.
PTPRD Mutations in Lung Cancer
| Sample | Histological type | No. of exon | (nucleotide change) | Predicted effect | mRNA levela |
|---|---|---|---|---|---|
| Cell line | |||||
| Ma29 | ADC | 11 | (C1184T: Homo) | Ala395Val | 0.0015 |
| H23 | ADC | 11 | (C1201T: Homo) | Arg401Trp | 0.053 |
| Sq-5 | SQC | 20 | (C3299T: Hetero) | Thr1100Met | 0.00068 |
| H1155 | LCC | 14 | (C2057T: Hetero) | Thr686Ile | 0.035 |
| PC13 | LCC | 20 | (A3164G: Hetero) | Asp1055Gly | 0.010 |
| Lu65 | LCC | 32 | (G5258T: Homo) | Gly1753Cys | 0.00047 |
| H2171b | SCC | 5 | (G460T: Homo) | Asp154Tyr | 0.025 |
| H526 | SCC | 17 | (A2443G: Hetero) | Lys815Glu | 0.70 |
| Surgical specimen | |||||
| Na68Tb | SQC | 4 | (G235T: Hetero) | Gly79STOP | 0.10 |
| Na182Tb | SQC | 21 | (TG3472–3473AT: Hetero) | Trp1158Met | 0.27 |
| S171Tb | SCC | 15 | (G2206T: Hetero) | Val1736Leu | Not tested |
| 1662Tb | SCC | 17 | (C IVS17+16 T: Hetero) | Unknown | Not tested |
a
Relative expression level to noncancerous lung tissues.
b
Validated to be somatic mutation.