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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Radiat Res. 2010 Aug;174(2):216–227. doi: 10.1667/RR1866.1

FIG. 4.

FIG. 4

Induction of DNA damage in bystander cells (not labeled with 3HdC). Panel A: Hoechst staining of DNA. Panel B: BrdU immunostaining. The images show a bystander cell (unlabeled) with a micronucleus and a nucleoplasmic bridge (bottom) along with a radiolabeled (BrdU+) cell with no micronuclei (top). Panel C: Micronucleus frequencies in bystander cells in the absence or presence of BrdU in the 3HdC-labeled cells and in the absence or presence of a 4-Gy challenge dose of γ rays. Background micronucleus frequencies in sham-labeled and sham-irradiated samples varied from 2% to 5% in different experiments (see also Table 2).