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General design of PEG nanocarriers conjugated to SQV prodrug and biotin/retro-inverso CK-Tat9 or CK(stearate)Tat9 peptides. The prodrug is attached through a reversible ester bond, whereas the cell-penetrating peptides are attached through reducible disulfide bonds. PEG is attached through stable amide bonds and biotin is attached through PEG spacer. The nanocarrier shown here releases the SQV.
