Table 1.
Impact of pregnancy on survival in patients with melanoma
| AUTHOR | PATIENTS (n) | SURVIVALa | STAGE |
|---|---|---|---|
| Stensheimd 2009 | 160 pregnant, 126 lactating, 4,460 age, gender-matched controls | (11.9 years) Pregnant HR=1.52, P=0.047 Lactating HR=1.10, P=NS Controls HR=1.00 |
All Stages |
| Silipob 2006 | 10 pregnant 30 age, anatomic site, stage controls |
(5 years) P=NS | pTis, pT1a, pT2a, pT3a, pT4ac |
| O'Mearad 2005 | 149 pregnant, 263 postpartum, 2,451 age-matched controls | Pregnant HR=0.79 Postpartum HR=0.58 Controls HR=1.00; P=NS |
All Stages |
| Lensd 2004 | 185 pregnant, 5,348 age-matched controls | (12.9 years) 85% pregnant; 82% nonpregnant P=NS |
Clinically localized |
| Daryananib 2003 | 46 pregnant, 368 age-, gender-matched controls | (10 years) Stage 1: P=NS; 88% pregnant; 86% nonpregnant Stage 2: P=NS; 67% pregnant; 73% nonpregnant |
1, 2c |
| Traversb 1995 | 45 pregnancy associated,e 420 age-matched controls | (5.4 years) 88.4% pregnant; 82.5% nonpregnant P value not given |
Clinically localized |
| MacKieb 1991 | 92 pregnant, 85 never pregnant, 143 completed all pregnancies, 68 between pregnancies | P=NS | Clinically localized |
| Slingluffb 1990 | 100 pregnant, 86 age-matched controls | (mean 6.8 years) 75% pregnant; 77% control P=NS |
All stages |
| Wongb 1989 | 66 pregnant, 619 controls matched for thickness, Clark's level, anatomic site, and histopathology | (5 years) 86% pregnant; 87% control P=NS |
Clinically localized |
| Reingtenb 1985 | 58 pregnant, 585 controls matched for age, primary site, disease stage, Clark's level, tumor thickness, ulceration, histologic type | (5 years) P=NS |
Clinically localized |
| Houghtond 1981 | 12 pregnant, 175 controls matched for age, anatomic site, stage at diagnosis | (5 years) 55% pregnant 58% nonpregnant |
All stages |
| Shiub 1976 | Stage 1: 20 pregnant 36 age-matched nulliparous controls Stage 2: 14 pregnant 11 age-matched nulliparous controls | (5 years) Stage 1: P=NS; 80% pregnant 83% nulliparous Stage 2: P<0.05*; 29% pregnant 55% nulliparous |
1f, 2g |
HR=hazard ratio (Cox proportional hazards model); NS=not significant
a
Overall survival
b
consecutive case series
c
American Joint Committee on Cancer (AJCC) staging (Balch, 2001)
d
small population-based studies
e
pregnant or within a year of delivery
f
melanoma localized to the primary site
g
metastases confined to regional lymph nodes
h
statistically significant difference between the pregnant and nulliparous groups