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. Author manuscript; available in PMC: 2010 Aug 16.
Published in final edited form as: Clin Cancer Res. 2009 Jun 23;15(13):4431–4438. doi: 10.1158/1078-0432.CCR-08-3330

Table 3.

Combined MSI/cyclin D1 category and patient mortality in colon cancer

Combined
MSI/cyclin
D1 category		 Total n Colon cancer–specific
mortality
 Overall
mortality
Deaths/
person-
years		 Univariate
HR
(95% CI)		 Stage-
matched HR
(95% CI)		 Multivariate
HR
(95% CI)		 Deaths/
person-
years		 Univariate
HR
(95% CI)		 Stage-
matched HR
(95% CI)		 Multivariate
HR
(95% CI)
MSS/MSI-low
graphic file with name nihms-186262-t0003.jpg Cyclin D1 (−) 242 82/1769 1 (Reference) 1 (Reference) 1 (Reference) 118/1769 1 (Reference) 1 (Reference) 1 (Reference)
Cyclin D1 (+) 245 57/2199 0.61
(0.43-0.85)		 0.60
(0.42-0.87)		 0.52
(0.35-0.78)		 101/2199 0.71
(0.54-0.92)		 0.69
(0.52-0.91)		 0.65
(0.48-0.87)
MSI-high
graphic file with name nihms-186262-t0004.jpg Cyclin D1 (−) 29 1/303 0.080
(0.011-0.58)		 0.14
(0.02-1.04)		 0.10
(0.01-0.78)		 6/303 0.31
(0.13-0.70)		 0.42
(0.18-0.97)		 0.29
(0.12-0.70)
Cyclin D1 (+) 80 13/591 0.45
(0.25-0.80)		 0.67
(0.36-1.25)		 0.40
(0.18-0.86)		 34/591 0.86
(0.58-1.26)		 1.09
(0.73-1.63)		 0.65
(0.39-1.10)

NOTE: The multivariate, stage-matched (stratified) Cox model included the combined MSI/cyclin D1 category, age, year of diagnosis, sex, family history of colorectal cancer, BMI, tumor location, grade, KRAS, BRAF, p53, p21, p27, COX-2, FASN, LINE-1 methylation, and CIMP. Pinteraction (cyclin D1 and MSI) = 0.061 for colon–cancer specific mortality; Pinteraction (cyclin D1 and MSI) = 0.008 for overall mortality.