Figure 3.
Characterization of ATP-β posttranslational modifications. A, Distribution of changing ATP-β on the 2DE gels. The unmodified form (marked with a thicker arrow) and fragments are indicated by arrows and accompanied by fold change values. B, Representative dephosphorylation gel for ATP-β. DHF is shown in red (Cy5), CRT in green (Cy3), and the AP-treated pool (AP) in blue (Cy2). C, Representative BN-PAGE/Western blot for ATP-β. Biological replicates are shown (3 sham-operated controls, 5 DHF, and 4 CRT). D, Typical MS/MS profile for the phosphopeptide FT*QAGSEVSALLGR. The MS/MS spectrum is provided, together with a schematic in which the mass values for all b- and y-ions series are reported.