Histopathology of microembolic infarcts. (A) A representative coronal section showing 2 cortical infarcts (arrows) 72 hours after injection of microspheres (10μm diameter, 20,000 particles; original magnification, ×12.5). (B) Although the majority of infarcts were in the ipsilateral cortex, the hippocampal formation also showed microinfarcts in a few brains (original magnification, ×200). (C) Most cortical infarcts were centered around a small blood vessel (arrow) (original magnification, ×200). (D) High-power image of a representative cortical microinfarct demonstrating the characteristic shrunken, eosinophilic neurons with pyknotic nuclei (arrowheads) adjacent to intact neurons at the infarct edge (original magnification, ×400).