TABLE 1.
Occurrence and Electrophysiological Properties of Microembolic CSDs
| Microemboli | Diameter (μm) | Volume (μl) | Particles | No. | Occurrence | Latency (min) | Duration (sec) | Amplitude (mV) |
|---|---|---|---|---|---|---|---|---|
| Saline | — | 10 | — | 8 | 0 | — | — | — |
| Air | — | 0.5 | — | 6 | 6 | 1.3 [1.2–1.6] | 56 [38–210] | 23 [21–34] |
| Microspheres | 20 | 5 | 7,000 | 10 | 10 | |||
| 10 | 0.5 | 10,000 | 5 | 0 | — | — | — | |
| 10 | 1 | 20,000 | 16 | 8 | 1.1 [0.6–1.6] | 62 [47–146] | 23 [18–25] | |
| 10 | 10 | 200,000 | 9 | 8 | 1.2 [0.8–1.5] | 77 [31–196] | 25 [22–27] | |
| 5 | 1.5 | 225,000 | 8 | 1 | 2 | 43 | 14 | |
| Cholesterol | <70 | 15 | 4,000 | 12 | 8 | 9.9 [6.4–18.1]a | 148 [122–470]a | 23 [18–28] |
CSD duration was measured from baseline to baseline. CSD latency is measured between injection of microemboli and onset of CSD. Data are presented as median [25–75% range].
a
p < 0.05 vs. air or microspheres.
CSD = cortical spreading depression; No. = number of animals.