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Patients >18 yo with significant (≥70 % luminal diameter narrowing of at least one major coronary artery) coronary artery disease.
LVEF ≤45% (by echocardiogram) and limiting angina (Class II to IV) and /or HF (NYHA class II - III).
Patients should be on maximal medical therapy.
Presence of reversibility by SPECT (adenosine stress) and/or viability as identified by NOGA.
Coronary artery disease not well suited to any other type of revascularization procedure (percutaneous or surgical) in the target region of the ventricle.
Hemodynamic stability as defined by systolic BP ≥80 mmHg without IV pressors or support devices.
Females of childbearing potential must be willing to use two forms of birth control for the duration of the study.
A signed consent form approved by the institutional review board.