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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Arthritis Rheum. 2010 Aug;62(8):2206–2218. doi: 10.1002/art.27528

Figure 3. OA cluster cell apoptosis and calcification.

Figure 3

Localization of TUNEL-positive cells, calcium deposits and pyrophosphate-generating enzymes in menisci from OA-affected human knees. The left panel shows apoptotic cells, many in clusters, in the vicinity of (alizarin red-positive) calcified areas. The right panel shows cells immediately bordering calcifications. Staining for plasma cell membrane glycoprotein (PC-1), autotaxin (ATX) and B10 is also prominent at sites of calcification and in areas with TUNEL-positive cells. CILP: cartilage intermediate layer protein. Modified from (131).

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