Table 1.
Gene and protein expression patterns in OA cartilage cell clusters.
Receptors, Kinases, Transcription factors |
Sox9(73,138) |
Runx2(122) | |
C-maf (99) | |
Leptin/ Leptin receptor (28) | |
c-Fos,c-Jun(AP-1)(30) | |
HMGB1 (100) | |
Cytokines, Growth factors |
BMP-7(OP-1)(101) |
FGF2(102) | |
BMP-2,−4,−6(103) | |
PGE2, COX-1,−2(104) | |
Histamine (105) | |
S-100(106) | |
IL-1β,TNFa(107) | |
Pleiotrophin(123) | |
WISP3 (110) | |
ECM, ECM-degrading Enzymes |
Aggrecan (72,73) |
Procollagen (64) | |
Col I (72) | |
Col II (64, 69, 72, 73) | |
Col VI (23) | |
Col X (120) | |
TIHP-1 (54) | |
5ZP(12) | |
MMP-1,−8,−13(107) | |
MMP-2, −3, −8,−9(108) | |
ADAMTS-10(109) | |
Cathepsin K (113), D (114), B (115) | |
Suits (116) | |
Syndecan-4(116) | |
Cell Death | Apoptosis (103,111) |
Autophagy (111, 112) | |
Progenitor Cell Markers |
Notch-1 (118,138) |
Stro-1 (138, 116, 141) | |
VCAM-1 (138) | |
Ann ex in VI (42) | |
Plelotrophln(123) |