Figure 1. Protective effect of Hst-5 on C. albicans viability (CFU/g tissue) using an ex vivo model of oral infection.
(A) Significant decrease in C. albicans viable counts recovered from tongues infected in the presence of increasing Hst-5 concentrations demonstrating a dose-dependent inhibitory effect for Hst-5 on C. albicans (B) In contrast, the anti-candidial effect of Hst-5 was inversely proportional to C. albicans cell density where based on percentage of Hst-5 killing, the susceptibility of C. albicans to Hst-5 decreased with increasing cell density. Error bars indicate the standard errors of the means. No significant difference is seen between 0-50μg/ml Hst-5 concentration (p>0.05). For all other values p<0.05.