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Tumor derived mutations in FNIII domains of PTPρ are defective in cell-cell aggregation. Sf9 cells expressing the mutated PTPρ proteins were allowed to aggregate for 30 minutes prior to imaging. Scale bar equals 100μm. The percentage of Sf9 cell-cell aggregation for each mutant protein was calculated from a minimum of three experiments. An asterisk indicates a statistically significant reduction in aggregation (p<0.008).
