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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Clin Cancer Res. 2010 Jul 2;16(16):4217–4225. doi: 10.1158/1078-0432.CCR-10-0777

Fig. 6. ABT-263 has a higher albumin binding affinity than ABT-737.

Fig. 6

The binding capacity of ABT-737 (solid lines) and ABT-263 (dotted lines) to human serum albumin (HSA) was investigated using a fluorescence polarization assay. A, to measure binding to site 2 on HSA-IIIA, dansyl sarcosine was used as a probe. In this assay the IC50 was 711 and 37 μM for ABT-737 and ABT-263, respectively. B, to measure binding to site 1 on HSA-IIA, dansyl L-glutamate was used as a probe. The IC50 was >1000 and 145 μM for ABT-737 and ABT-263, respectively.