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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Eur J Neurosci. 2010 Jul 14;32(3):368–379. doi: 10.1111/j.1460-9568.2010.07299.x

Figure 8.

Figure 8

Selective 5-HT1A and 5-HT1B antagonists block the effects of agonists. A. Frequency response plots for 6 different neurons illustrating that the selective antagonists NAS-181 (5-HT1B receptor; top plots), WAY-100135 (5-HT1A; middle plots) and MM 77 (5-HT1A; lower plots) partially or totally reverse the effects of selective agonists (left plots) and of serotonin (right plots). B. Mean effects of different 5-HT1B (black bars) and 5-HT1A (gray bars) receptor antagonists in combination with agonists on changes in the spike rate [(drug-control)/control].