Figure 1.

Dasatinib inhibits calvarial osteoblast (PMOs) proliferation. A, cell density and morphologic characteristics after treatment of PMOs with various concentrations of dasatinib for 72 h. PMOs were cultured in 10% FBS or in 0.1% BSA as indicated. B, quantification of cell numbers. C. Time course of effect of dasatinib on PMOs proliferation. The PMOs were cultured in 10% FBS and treated without or with 50 nM dasatinib. Data are means ± SD. *P < 0.05 vs. control (DMSO). The experiment was repeated three times with similar results.