Figure 5.
Effects of P60 and P80 PLAD protein on autoantibody production and skin deposition in MRL/lpr mice. At 16 weeks of age, OD450 values of serum IgG (1:4) (A) and serum anti-dsDNA antibody (1:4) in MRL/lpr mice treated with PBS or P60 or P80 PLAD protein. *P < 0.01 and ** P> 0.05 (P value represents P60 or P80 PLAD vs PBS treatment). (C) Representative immunohistochemistry staining of IgG deposition in face skin injury of MRL/lpr mice. Skin from MRL/lpr mice treated with PBS or P80 PLAD or P60 PLAD at the age of 32 weeks.