Table 1.
Genome-wide significant loci for 2-h glucose during an OGTT from 26 studies in nondiabetic individuals
| Discovery | Replication | Discovery and replication | Discovery and replication (FG adj) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | Position (bp) |
Nearest gene |
Alleles (+/−) |
Freq (+)1 |
Effect (s.e.m.) mmol/l |
P value | Effect (s.e.m.) mmol/l |
P value | Effect (s.e.m.) mmol/l |
P value |
P value (no BMI) |
Effect (s.e.m.) mmol/l |
P value |
P value (no BMI) |
| rs1260326 | 2 | 27584444 | GCKR | T/C | 0.40 | 0.09 (0.02) | 1.53 × 10−6 | 0.06 (0.01) | 5.33 × 10−6 | 0.07 (0.01) | 7.05 × 10−11 | 3.00 × 10−10 | 0.10 (0.01) | 9.23 × 10−21 | 2.26 × 10−21 |
| rs2877716 | 3 | 124577141 | ADCY5 | C/T | 0.77 | 0.10 (0.02) | 6.26 × 10−6 | 0.09 (0.01) | 1.21 × 10−11 | 0.09 (0.01) | 4.19 × 10−16 | 7.41 × 10−16 | 0.07 (0.01) | 1.68 × 10−11 | 7.98 × 10−12 |
| rs12243326 | 10 | 114778805 | TCF7L2 | C/T | 0.21 | 0.13 (0.02) | 1.20 × 10−9 | 0.05 (0.02) | 1.27 × 10−3 | 0.08 (0.01) | 4.23 × 10−10 | 1.12 × 10−7 | 0.07 (0.01) | 9.99 × 10−9 | 1.17 × 10−10 |
| rs17271305 | 15 | 60120272 | VPS13C | G/A | 0.42 | 0.09 (0.02) | 1.04 × 10−6 | 0.05 (0.02) | 1.58 × 10−3 | 0.06 (0.01) | 4.11 × 10−8 | 1.30 × 10−7 | 0.07 (0.01) | 4.33 × 10−11 | 8.41 × 10−11 |
| rs10423928 | 19 | 50874144 | GIPR | A/T | 0.18 | 0.15 (0.03) | 3.33 × 10−6 | 0.09 (0.01) | 2.30 × 10−11 | 0.09 (0.01) | 1.98 × 10−15 | 3.20 × 10−12 | 0.11 (0.01) | 2.56 × 10−20 | 5.94 × 10−18 |
| n11,268–15,234 | 15,103–30,121 | 30,337–43,104 | 30,114–42,354 | ||||||||||||
Results from fixed effects, inverse variance meta-analysis of 9 GWA (ARIC, BLSA, CHSstage1&2, CoLaus, DGI, Fenland, FHS, FUSION, Sorbs) and 17 follow-up studies (Amish, BotniaPPP, CHSstage3, DIAGEN, ELY, FrenchFamilyMembers, FrenchHaguenau, FrenchObeseAdults, FUSIONstage2, Hertfordshire, Inter99, METSIM, NHANES, RISC, Roche, ULSAM, Whitehall II) with adjustment for age, sex and BMI. Position based on hg18, NCBI build36. Combined discovery and replication P values for 2-h glucose adjusted for age and sex (no BMI), and further adjusted for fasting glucose are also presented. Replication meta-analysis results and joint discovery and replication meta-analysis results include proxy SNPs with r2 > 0.8 in HapMap CEU.
Allele frequencies based on HapMap phase II CEU sample. FG adj, adjusted for fasting glucose in addition to age, sex, BMI and study-specific covariates (center).