. Author manuscript; available in PMC: 2010 Aug 16.

Published in final edited form as: Nat Genet. 2010 Jan 17;42(2):142–148. doi: 10.1038/ng.521

Table 3.

Meta-analysis of T2D association studies for SNPs at previously unknown 2-h glucose–associated loci

							T2D fixed effects			T2D random effects

SNP	Chr	Nearest gene	Effect allele	n studies	n cases	n controls	OR (95% CI)	P value	I² (%)	OR (95% CI)	P value
rs2877716	3	ADCY5	c	25	35,869	89,798	1.12 (1.09–1.15)	4.8 × 10⁻¹⁸	35.2 (0–59.3)	1.12 (1.08–1.16)	9.4 × 10⁻¹¹
rs17271305	15	VPS13C	g	13	15,180	32,556	0.97 (0.94–1.00)	0.083	48.7 (0–72.8)	0.99 (0.94–1.04)	0.62
rs10423928	19	GIPR	a	16	19,091	38,508	1.07 (1.03–1.12)	1.8 × 10⁻⁴	39.3 (0–60.3)	1.07 (1.02–1.12)	9.6 × 10⁻³

Proxies rs11708067 with r² = 0.82 in HM CEU to rs2877716 used in eight studies; rs11717195 with r² = 0.95 in HM CEU used in two studies. Proxy rs12913951 with r² = 0.71 in HM CEU to rs17271305 used in two studies.

Proxy rs11672660 with r² = 0.95 in HM CEU to rs10423928 used in three studies.