Table 3.
The undertaker conformation-change operators that had the highest probability of success (improving the cost function when applied) for the last 300 generations of the optimization by undertaker for the SAM-T08 server on the server-only models. The “tweak” operators make tiny changes to one or two torsion angles; the “heal” operators replace a peptide plane with a canonical one; and the Backrub operators29 rotate a piece of the backbone a small amount about the axis between two CA atoms (2 apart for Backrub, further for BigBackrub) and make compensating rotations for the peptide planes at either end of rotated piece.
| Operator | % successful |
|---|---|
| TweakPsiSegment | 26.3 |
| TweakPeptide | 25.4 |
| TweakPsiSubtree | 20.2 |
| Backrub | 14.5 |
| HealPeptide | 14.3 |
| TweakPhiSubtree | 12.0 |
| TweakPhiSegment | 11.4 |
| TweakPsiPhiSegment | 7.9 |
| HealGap | 7.9 |
| BigBackrub | 7.6 |
| TweakPsiPhiSubtree | 7.6 |