Table 2.

Genes involved in chromatin-mediated control of secondary metabolism in Aspergillus nidulans

Gene	Function	Secondary Metabolism Phenotype*	Reference
hepA	Heterochromatin protein 1	ΔhepA results in increased production of ST	[40••]
clrD	H3K9 methyltransferase	ΔclrD results in increased production of ST, partial remediation of ST in ΔlaeA background	[40••]
hdaA	Histone deacetylase	ΔhdaA results in increased production of ST and PN. Partial remediation of ST/PN in ΔlaeA background	[38]
cclA	H3K4 methyltransferase (part of COMPASS complex)	ΔcclA resulted in production of secondary metabolites from cryptic clusters	[43••]
laeA	unknown	ΔlaeA results in loss of several secondary metabolites (ST, PN, TQ) and increased H3K9 methylation in the ST cluster	[37,40]

^*ST = sterigmatocystin, PN = penicillin, TQ = terrequinone A