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. 2010 May 18;21(6):739–749. doi: 10.1089/hum.2009.190

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Copyright 2010, Mary Ann Liebert, Inc.

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FIG. 3. — In vivo effects of GLA-αHer2 on SKOV-3 infection by Ad5. (A and B) Nude mice injected intraperitoneally with 4 × 10⁶ SKOV-3 cells 28 days before treatment were injected with 1 × 10⁹ Ad-GL-RC virus that had been mixed with control 293 cell supernatant or with the supernatant from GLA-αHer2-expressing cells. (A) Luciferase images were taken on day 24 after virus injection. (B) Two mice from each group in (A) were imaged after the abdominal cavity was opened to facilitate viewing 10 days after viral injection. (C) Nude mice injected intraperitoneally with 4 × 10⁶ SKOV-3 cells 21 days before virus treatment were injected with 1 × 10⁹ Ad-GL-RC or Ad-GL-FB-RC virus with or without prior incubation with GLA-αHer2 supernatant. Survival was monitored over time after this single treatment and was analyzed by Kaplan–Meier survival analysis. Statistical comparisons described in text were performed by log-rank analysis. Color images available online at www.liebertonline.com/hum.