Table 4.
Age 5 Cockroach Antigen-Induced PBMC Proliferation and IgE at Age 5 years
| Outcomes | ||||
|---|---|---|---|---|
| Anti-cockroach IgE ≥ 0.35 IU/ml | Total IgE (IU/ml) | |||
| Predictors |
Crude OR (95% CI) [n = 113] |
Adjusted OR (95% CI) [n = 78] |
Crude β [n = 124] |
Adjusted β [n = 85] |
| Positive cockroach-induced PBMC proliferation | 1.75 (0.69, 4.42) | 3.39 (1.05, 10.92) | 0.63 (p = 0.02) | 1.05 (p = 0.00) |
| Female sex | NA | 0.64 (0.22, 1.87) | NA | -0.80 (p = 0.02) |
| African American ethnicity (Reference = Dominican) |
NA | 01.12 (0.36, 3.46) | NA | 0.30 (p = 0.37) |
| Age 5 ETS exposed | NA | 0.83 (0.27, 2.53) | NA | -0.22 (p = 0.51) |
| Maternal history of asthma | NA | 1.20 (0.38, 3.77) | NA | 0.31 (p = 0.39) |
| Prenatal cockroach allergen in bed (μg/g dust) | NA | 0.71 (0.46, 1.12) | NA | -0.10 (p = 0.36) |
Results were based on univariate and multivariate, logistic and linear regression models. The endpoint anti-cockroach IgE is shown as odds ratio, and total IgE as regression coefficients with two-tailed p-values. Interaction terms each examined in a separate model [data not shown] demonstrated significant interactions between age 5 cockroach-induced PBMC proliferation with ethnicity (p = 0.04) and sex (p = 0.01) on age 5 anti-cockroach IgE. In stratified adjusted models, there were significant positive associations between age 5 cockroach-induced PBMC proliferation and age 5 anti-cockroach IgE amongst African Americans (β = 1.86, p = 0.00) and girls (β = 1.05, p = 0.00). Maternal asthma was defined as positive at either prenatal or 3-months postnatal time points. Cockroach prenatal allergen levels (μg/g of dust) are expressed as natural log-transformed values. OR, odds ratio. ETS, environmental tobacco smoke. NA, not applicable.