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PD-1–deficient mice have increased bacterial loads in the lungs after H37Rv aerosol infection, compared with wild-type mice. (A) cfu values determined in the lungs of wild-type and PD-1−/− mice, 2, 4, and 8 wk after low-dose H37Rv aerosol infection (50 CFU). Mean values of five mice at each timepoint are shown ± SD. (B) CFU values from organs of control and PD-1−/− mice at 4 wk postinfection with 320 CFU. Data are representative of three independent experiments. *P < 0.05.
