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Representative current waveforms and dose-response relations for S-nicotine and S-MPP. Agonist-induced current waveforms for (A) S-Nic on wild-type α4β2. (B) S-Nic on α4β2L119Lah. (C) S-MPP on wild-type α4β2. (D) S-MPP on α4β2L119Lah. Concentrations are in μM. (E) Dose-response relations for S-Nic and S-MPP on wild-type α4β2 or α4β2L119Lah.
