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. 2010 Jul 12;107(30):13438–13443. doi: 10.1073/pnas.1002423107

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Fig. 4. — Myc is up-regulated during pancreatic carcinogenesis and down-regulated in Kras;N2ko mice. (A) GSEA shows significantly enriched Myc signatures in Kras vs. Kras;N2ko pancreata isolated from 7-d-old mice (dark red, n = 2 and 4) and primary cancer cells (light red, n = 6 each). Roman numbers refer to detailed analysis in Tables S12 and S13. (B) Myc transcript levels increase during carcinogenesis in Kras pancreata at indicated time points. Values represent WT-to-Kras ratio of relative expression levels (n = 3 for each time point). (C) Expression of Myc is low in the normal pancreas and increases in PanIN lesions of Kras mice. (D) Kras;N2ko cancer cells (n = 4) show decreased Myc mRNA and protein expression compared with Kras cells (n = 5). (E) Immunohistochemical staining in Kras;N2ko-derived anaplastic PDAC shows lower expression of Myc compared with Kras PDAC. (Scale bar: 50 μm.)