Table 3.
Association of CIMP with clinicopathological parameters
| Variables | Grading | CIMP | P* | |
|---|---|---|---|---|
| negative n (%) | positive n (%) | |||
| Age(Years) | ≤50 | 8(22) | 28(78) | |
| > 50 | 10(34) | 19(66) | 0.272 | |
| Gender | Female | 2(33) | 4(67) | |
| Male | 16(27) | 43(73) | 0.666 | |
| PVTT | Negative | 13(30) | 31(70) | |
| Positive | 5(24) | 16(76) | 0.629 | |
| Preoperative AFP level(ng/ml) | ≤400 | 14(40) | 21(60) | |
| > 400 | 4(13) | 26(87) | 0.017 | |
| Histopathologic grading | Well+moderate | 14(30) | 33(70) | |
| Poor | 4(22) | 14(78) | 0.758 | |
| Tumor size(cm) | ≤5 | 8(28) | 21(72) | |
| > 5 | 10(28) | 26(72) | 0.986 | |
| Tumor number | Single | 11(48) | 12(52) | |
| Multiple | 7(17) | 35(83) | 0.007 | |
| Hangzhou criteria** | Yes | 12(43) | 16(57) | |
| No | 6(16) | 31(84) | 0.017 | |
PVTT, portal vein tumor thrombi; AFP, alpha-fetoprotein
** Apart from the presence of macrovascular invasion, Hangzhou criteria are matched if total tumor diameter ≤ 8 cm, or if, total tumor diameter > 8 cm, with histopathologic grade I/II and AFP ≤ 400 ng/mL [38].
*Pearson's Chi-square test or Fisher's exact test.