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Kinetic parameters of the wildtype and variant CYP2A6 constructs for the metabolism of nicotine.
| Km (μM) | Vmax (pmol/min/pmol CYP2A6) | Vmax/Km (nl/min/pmol CYP2A6) | |
|---|---|---|---|
| CYP2A6.1 | 7.0±0.7 | 0.53±0.04 | 8.0±0.6 |
| CYP2A6.17 | 33.4±3.3* | 0.36±0.03 | 1.1±0.1* |
| CYP2A6.V110L | 11.3±1.4 | 0.52±0.06 | 4.7±0.3* |
| CYP2A6.35 | 9.9±0.8 | 0.49±0.05 | 5.0±0.2* |
| CYP2A6.24 | 5.4±1.8 | 0.53±0.09 | 10.5±1.9 |
Data are presented as mean ± SEM of 2–7 independent experiments.
p<0.05 when compared to CYP2A6.1.
