Table 3.
Association between CYP1B1 Leu/Val polymorphism and EM levels in breast tissue and urine
| BREAST TISSUE pg/g wet tissue |
CYP1B1 Leu/Leu Mean (SE) |
CYP1B1 Leu/Val+ Val/Val Mean (SE) |
p-value (Kruskal-Wallis test) |
|---|---|---|---|
| Estrogens# | 373.7 (46.2) | 117 (28) | 0.02 |
| 2-hydroxylation Pathway | 54.7 (22.9) | 43.9 (8.3) | 0.79 |
| 16-hydroxylation Pathway | 141.8 (29.7) | 76.1 (13.2) | 0.07 |
| Total* | 570.5 (85.7) | 237.0 (25.2) | 0.02 |
| 2/16 ratio | 0.39 (0.15) | 0.73 (0.24) | 0.31 |
| URINE pg/mL | |||
| Estrogens | 37.4 (11.7) | 124.3 (81.2) | 0.79 |
| 2-hydroxylation Pathway | 73.3 (39.6) | 56.1 (19.2) | 0.6 |
| 16-hydroxylation Pathway | 216.6 (81.5) | 151.5 (84) | 0.3 |
| Total | 341.8 (132.3) | 335.5 (149.1) | 0.6 |
| 2/16 ratio | 0.34 (0.09) | 0.54 (0.16) | 0.43 |
*P value test for trend = 0.05
#P value test for trend 0.06