Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding constants of amantadine and rimantadine to M2 ion channels at high drug concentrations
| Amantadine |
Rimantadine |
|||||
| M2 variant | Binding affinity KD, μM | SD, μM | n | Binding affinity KD, μM | SD, μM | n |
| Wild type | 400 (360) | 100 (90) | 3 | 500 | 150 | 3 |
| V27A | 380 (480) | 37 (120) | 3 | 810 | 270 | 3 |
| D44A | NB | NB | 3 | NB | NB | 3 |
| S31N | NB | NB | 3 | NB | NB | 3 |
The binding affinities displayed in parentheses were derived from an independent SPR study (26).
NB denotes no specific binding to M2 ion channels.
