Table 1.
Structural analysis of femurs from HIV-1 Tg and WT rats by μCT
| Index | WT rats | HIV-1 rats | Change, % | P value* |
| Trabecular | ||||
| TV, mm3 | 14.8 ± 1.1 | 11.5 ± 1.1 | −22.4 | 0.0000001 |
| BV, mm3 | 4.9 ± 0.8 | 2.5 ± 0.5 | −47.9 | 0.0000005 |
| BV/TV, % | 33.2 ± 4.0 | 22.4 ± 4.3 | −32.5 | 0.0000859 |
| Tb. Th, μm | 72.1 ± 6.2 | 65.9 ± 5.3 | −8.5 | 0.0562849 |
| Tb. N/mm | 6.6 ± 0.7 | 4.7 ± 1.0 | −29.1 | 0.0002578 |
| Conn. D., per mm3 | 322.2 ± 38.3 | 264.0 ± 121.7 | −18.1 | 0.0116980 |
| Tb. Sp, μm | 199.9 ± 19.8 | 273.6 ± 53.3 | +36.9 | 0.0015729 |
| TV. D, mg HA/cm3 | 405.3 ± 43.5 | 292.9 ± 54.1 | −27.7 | 0.0003269 |
| Cortical | ||||
| Co. Vol, mm3 | 8.1 ± 0.3 | 6.7 ± 1.0 | −18.7 | 0.03296 |
| Co. Th, μm | 592.0 ± 81.4 | 565.2 ± 47.8 | −12.5 | 0.55463 |
Trabecular indices, including TV, BV, trabecular thickness (Tb. Th.), trabecular space (Tb. Sp.), trabecular number (Tb. No.), trabecular connectivity density (Conn. D.), and cortical indices cortical thickness (Co. Th.) and cortical bone volume (Co. Vol.), were computed from μCT scans. The data are presented as the mean ± SD of 8 WT and 11 HIV-1 rats per group, age 8–9 mo.
*Student’s t test.