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. 2010 Jul 16;107(31):13608–13613. doi: 10.1073/pnas.1006007107

Fig. 3.

Fig. 3.

(A) Transmission electron microscopy (TEM) image of 1K1-encapsulated nanoparticles (1K1-NP) (Bar = 500 nm). (B) Size distribution (in nm) of the 1K1-encapsulated nanoparticles by dynamic light scattering experiment. (C) Graph shows release kinetics of 1K1 from the nanoparticle when incubated in PBS at room temperature. The values on the Y-axis represent the amount of 1K1 released from the 1K1-NP in ug unit. (D) Effect of Met inhibitor, PHA 665752, on 1K1-NP induced HUVECs proliferation at 48 h. (E) Effect of PI3 kinase inhibitor, LY294002, on 1K1-NP induced HUVECs proliferation at 48 h. (F) Effect of MAP kinase inhibitor, PD98059, on 1K1-NP induced HUVECs proliferation at 48 h. The data represent mean ± SEM from n = 3. *** P < 0.001 vs. vehicle-treated control; ** P < 0.01 vs. vehicle-treated control; ### P < 0.001 vs. 1K1(10-7 M); ## P < 0.01 vs. 1K1(10-7 M); # P < 0.05 vs. 1K1(10-7 M).