Fig. 6.

Effect of 1K1 (200 ng/plug) and 1K1-NP (200 ng/plug) induced angiogenesis in growth-factor-reduced matrigel implants in vivo. Upper (A–D) shows gross morphology of the implants after everting the murine skin, and Bottom (E–H) shows cross sections where blood vessels are delineated with von Willebrand factor immunolabeling and appear red. Nuclei were counterstained with DAPI and appear blue. Images were captured at 512 × 512 pixels resolution. A and E: vehicle, B and F: empty NP, C and G: 1K1, D and H: 1K1 NP.