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. 2010 Jul 16;107(31):13666–13671. doi: 10.1073/pnas.1003553107

Fig. 6.

Fig. 6.

Comparison of the structural basis for the inhibition of GDP release by YM-254890 and the GoLoco peptide. (A) Surface representation of the Gαi/q–YM-254890 complex (PDB ID: 3AH8). (B) Surface representation of the Gαi1–GoLoco peptide complex (PDB ID: 1KJY). The GoLoco peptide is shown in blue. (C) Schematic representation of (A). YM-254890 directly inhibits a hinge motion of the helical domain away from the GTPase domain. (D) Schematic representation of (B). The GoLoco peptide may act as a Gα clamp that restricts the movement of the two domains (14, 25).