Fig. 6.

A model for SNC1-mediated defense activation through repression of negative regulators of defense. When plants are not under pathogen attack, R protein-mediated immune responses are repressed by DND1, DND2, and other negative regulators. The mutation in snc1 or overexpression of TPR1 leads to association of SNC1 and TPR1 in a protein complex. The association of SNC1 and TPR1 results in activation of the TPR1 corepressor. Activated TPR1 represses the expression of negative regulators of defense responses, which leads to activation of immune responses.