Table 3.
Accuracy of various eGFR cutoffs to define kidney disease
| eGFR (mL/min per 1.73 m2) |
Kidney disease defined as cystatin C> 1.23 mg/L |
|||||||
|---|---|---|---|---|---|---|---|---|
| No. of cases/No. at risk | Prevalence | Sensitivity | Specificity | Positive predictive value | Negative predictive value | False positive rate | False negative rate | |
| MDRD equation | ||||||||
| ≥60 | 104/3831 | 2.7% | ||||||
| <60 | 340/797 | 42.7% | 76.6% | 89.1% | 42.7% | 97.3% | 10.9% | 23.4% |
| ≥45 | 287/4134 | 6.5% | ||||||
| <45 | 157/207 | 75.8% | 35.4% | 98.8% | 75.8% | 93.5% | 1.2% | 64.6% |
| Cockcroft–Gault equation | ||||||||
| ≥60 | 124/3863 | 3.2% | ||||||
| <60 | 320/765 | 6.9% | 72.1% | 89.4% | 41.8% | 96.8% | 10.6% | 27.9% |
| ≥45 | 272/4403 | 6.2% | ||||||
| <45 | 172/225 | 76.4% | 38.7% | 98.7% | 76.4% | 93.8% | 1.3% | 61.3% |
| Mayo equation | ||||||||
| ≥60 | 274/4406 | 6.2% | ||||||
| <60 | 170/222 | 76.6% | 38.3% | 98.8% | 76.6% | 93.8% | 1.2% | 61.7% |
| ≥45 | 364/4540 | 8.0% | ||||||
| <45 | 80/88 | 90.9% | 18.0% | 99.8% | 90.9% | 92.0% | 0.2% | 82.0% |
| Ad hoc CKD definitiona | ||||||||
| Absent | 266/4382 | 6.1% | ||||||
| Present | 178/246 | 72.3% | 40.1% | 98.4% | 72.4% | 93.9% | 1.6% | 59.9% |
Note:
a
CKD defined in the current study as either MDRD equation eGFR<45 mL/min per 1.73 m 2 or Mayo equation eGFR <60 mL/min per 1.73 m2.
Abbreviations: eGFR, estimated glomerular filtration rate; MDRD, modification of diet in renal disease; CKD, chronic kidney disease.